Secondly: Many of you have been good enough to post your experiences with attempting to "unsubscribe" from spam or scams, and report that the attacks increased afterwards. This is also a good reason not to "unsubscribe". The comments posted here suggested that the 'unsubscribe' button is being used to verify working email addresses for further spamming.
Thirdly: It is a lot more fun to report them to the FCC, FBI, or whatever makes you feel better, while posting their crap on a site like this, making fun of them, and leaving their sender information available for any old free-range hacker who gets bored and pulls the losers' information off sites like this for their shenanigans. I have had a couple anonymous comments suggest that to be the case, and I think that is a good use for that sender information.
But of course, it is up to you what you do. In my experience of having received all of this garbage to my inbox: never respond in any way, shape, or form to these emails. You don't want yourself on the radar of anyone associated with these entities. The 'unsubscribe' link can be just as much a scam as anything else in the message.